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- Title
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats.
- Authors
Deblon, N; Bourgoin, L; Veyrat-Durebex, C; Peyrou, M; Vinciguerra, M; Caillon, A; Maeder, C; Fournier, M; Montet, X; Rohner-Jeanrenaud, F; Foti, M
- Abstract
mTOR inhibitors are currently used as immunosuppressants in transplanted patients and as promising anti-cancer agents. However, new-onset diabetes is a frequent complication occurring in patients treated with mTOR inhibitors such as rapamycin (Sirolimus). Here, we investigated the mechanisms associated with the diabetogenic effects of chronic Sirolimus administration in rats and in in vitro cell cultures.
- Publication
British journal of pharmacology, 2012, Vol 165, Issue 7, p2325
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2011.01716.x