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- Title
Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats.
- Authors
Polito, Francesca; Marini, Herbert; Bitto, Alessandra; Irrera, Natasha; Vaccaro, Mario; Adamo, Elena Bianca; Micali, Antonio; Squadrito, Francesco; Minutoli, Letteria; Altavilla, Domenica
- Abstract
Ovariectomy accelerates age-related skin changes as adequate oestrogen levels are required to control structural integrity and functional capacity of skin. Genistein, a soy-derived isoflavone, has been tested in anti-ageing cosmetic preparations with interesting results on skin elasticity, photoaging and skin cancer prevention. We investigated the effects of genistein aglycone and compared them with systemic raloxifene hydrochloride and 17-α-ethinyloestradiol on skin changes in aged, ovariectomized (OVX) rats.
- Publication
British journal of pharmacology, 2012, Vol 165, Issue 4, p994
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2011.01619.x