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- Title
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
- Authors
Kannaiyan, Radhamani; Hay, Hui Sin; Rajendran, Peramaiyan; Li, Feng; Shanmugam, Muthu K; Vali, Shireen; Abbasi, Taher; Kapoor, Shweta; Sharma, Ashish; Kumar, Alan Prem; Chng, Wee-Joo; Sethi, Gautam
- Abstract
Activation of pro-inflammatory transcription factors NF-κB and signal transducer and activator of transcription 3 (STAT3) is one of the major contributors to both pathogenesis and chemoresistance in multiple myeloma (MM), which results in high mortality rate. Thus, in the present study, we investigated whether celastrol could suppress the proliferation and induce chemosensitization of MM cells by interfering with NF-κB and STAT3 activation pathways.
- Publication
British journal of pharmacology, 2011, Vol 164, Issue 5, p1506
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2011.01449.x