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- Title
NPY receptors as potential targets for anti-obesity drug development.
- Authors
Yulyaningsih, Ernie; Zhang, Lei; Herzog, Herbert; Sainsbury, Amanda
- Abstract
The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia. Due to the initial lack of pharmacological tools that are active in vivo, functions of the different Y receptors have been mainly studied in knockout and transgenic mouse models. However, over recent years various Y receptor selective peptidic and non-peptidic agonists and antagonists have been developed and tested. Their therapeutic potential in relation to treating obesity and other disorders of energy homeostasis is discussed in this review.
- Publication
British journal of pharmacology, 2011, Vol 163, Issue 6, p1170
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2011.01363.x