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- Title
In rat renal fibroblasts, mycophenolic acid inhibits proliferation and production of the chemokine CCL2, stimulated by tumour necrosis factor-alpha.
- Authors
Chang, Hong-Wei; Wu, Vin-Cent; Wu, Kwan-Dun; Huang, Hong-Yu; Hsieh, Bor-Shen; Chen, Yung-Ming
- Abstract
Renal fibroblasts play a pivotal role in the development of tubulointerstitial fibrosis, a condition highly predictive of progression towards end-stage renal disease. The present study investigated the anti-mitogenic and anti-inflammatory effects of an inhibitor of inosine monophosphate dehydrogenase, mycophenolic acid (MPA) and the mechanisms underlying its action in normal rat kidney fibroblasts (49F cells).
- Publication
British journal of pharmacology, 2010, Vol 160, Issue 7, p1611
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2010.00837.x