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- Title
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.
- Authors
Feng, Ying; Huang, Su-ling; Dou, Wei; Zhang, Song; Chen, Jun-hua; Shen, Yu; Shen, Jian-hua; Leng, Ying
- Abstract
11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome. Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple biological activities. Here, we investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.
- Publication
British journal of pharmacology, 2010, Vol 161, Issue 1, p113
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2010.00826.x