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- Title
Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans.
- Authors
Sciorati, Clara; Buono, Roberta; Azzoni, Emanuele; Casati, Silvana; Ciuffreda, Pierangela; D'Angelo, Grazia; Cattaneo, Dario; Brunelli, Silvia; Clementi, Emilio
- Abstract
Current therapies for muscular dystrophy are based on corticosteroids. Significant side effects associated with these therapies have prompted several studies aimed at identifying possible alternative strategies. As inflammation and defects of nitric oxide (NO) generation are key pathogenic events in muscular dystrophies, we have studied the effects of combining the NO donor isosorbide dinitrate (ISDN) and the non-steroidal anti-inflammatory drug ibuprofen.
- Publication
British journal of pharmacology, 2010, Vol 160, Issue 6, p1550
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2010.00809.x