We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.
- Authors
Rollema, H; Shrikhande, A; Ward, K M; Tingley, F D, 3rd; Coe, J W; O'Neill, B T; Tseng, E; Wang, E Q; Mather, R J; Hurst, R S; Williams, K E; de Vries, M; Cremers, T; Bertrand, S; Bertrand, D
- Abstract
Smoking cessation trials with three high-affinity partial agonists of alpha4beta2 neuronal nicotinic acetylcholine receptors (nAChRs) have demonstrated differences in their clinical efficacy. This work examines the origin of the differences by taking into account brain exposure and pharmacological effects at human alpha4beta2 nAChRs.
- Publication
British journal of pharmacology, 2010, Vol 160, Issue 2, p334
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2010.00682.x