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- Title
LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation.
- Authors
Tributino, J L M; Santos, M L H; Mesquita, C M; Lima, C K F; Silva, L L; Maia, R C; Duarte, C D; Barreiro, E J; Fraga, C A M; Castro, N G; Miranda, A L P; Guimaraes, M Z P
- Abstract
Compound LASSBio-881 is an orally effective antinociceptive that binds to cannabinoid receptors and is active mainly on the neurogenic component of pain models. We investigated whether transient receptor potential vanilloid subfamily type 1 (TRPV1) channels are involved in the effects of LASSBio-881.
- Publication
British journal of pharmacology, 2010, Vol 159, Issue 8, p1716
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2010.00672.x