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- Title
Long-term effects of losartan on structure and function of the thoracic aorta in a mouse model of Marfan syndrome.
- Authors
Yang, H H Clarice; Kim, Jong Moo; Chum, Elliott; van Breemen, Cornelis; Chung, Ada W Y
- Abstract
During development of thoracic aortic aneurysms in a mouse model of Marfan syndrome, upregulation of matrix metalloproteinase (MMP)-2 and -9 was accompanied by compromised aortic constriction and endothelium-dependent relaxation. Losartan has been proposed for the prevention of thoracic aortic aneurysm. We hypothesized that losartan would suppress MMP-2/-9 activation and improve aortic vasomotor function in this model.
- Publication
British journal of pharmacology, 2009, Vol 158, Issue 6, p1503
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2009.00443.x