We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.
- Authors
Lu, P; Mamiya, T; Lu, L L; Mouri, A; Zou, Lb; Nagai, T; Hiramatsu, M; Ikejima, T; Nabeshima, T
- Abstract
Accumulated evidence suggests that oxidative stress is involved in amyloid beta (Abeta)-induced cognitive dysfunction. Silibinin (silybin), a flavonoid derived from the herb milk thistle (Silybum marianum), has been shown to have antioxidative properties; however, it remains unclear whether silibinin improves Abeta-induced neurotoxicity. In the present study, we examined the effect of silibinin on the memory impairment and accumulation of oxidative stress induced by Abeta(25-35) in mice.
- Publication
British journal of pharmacology, 2009, Vol 157, Issue 7, p1270
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2009.00295.x