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- Title
Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.
- Authors
Bailey, C P; Oldfield, S; Llorente, J; Caunt, C J; Teschemacher, A G; Roberts, L; McArdle, C A; Smith, F L; Dewey, W L; Kelly, E; Henderson, G
- Abstract
The ability of an agonist to induce desensitization of the mu-opioid receptor (MOR) depends upon the agonist used. Furthermore, previous data suggest that the intracellular mechanisms underlying desensitization may be agonist-specific. We investigated the mechanisms underlying MOR desensitization, in adult mammalian neurons, caused by morphine (a partial agonist in this system) and DAMGO (a high-efficacy agonist).
- Publication
British journal of pharmacology, 2009, Vol 158, Issue 1, p157
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2009.00140.x