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- Title
The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC.
- Authors
Liptrott, N J; Penny, M; Bray, P G; Sathish, J; Khoo, S H; Back, D J; Owen, A
- Abstract
The function of transporters in peripheral blood mononuclear cells (PBMC) has been characterized, but less is known about cytochrome P450 (CYP) enzyme function in these cells. Given that cytokines are dysregulated in many diseases, the purpose of this work was to assess the impact of cytokines on the expression of CYPs, transporters and chemokine receptors in PBMC.
- Publication
British journal of pharmacology, 2009, Vol 156, Issue 3, p497
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2008.00050.x