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- Title
Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation.
- Authors
Cattaruzza, F; Cottrell, G S; Vaksman, N; Bunnett, N W
- Abstract
The metalloendopeptidase endothelin-converting enzyme 1 (ECE-1) is prominently expressed in the endothelium where it converts big endothelin to endothelin-1, a vasoconstrictor peptide. Although ECE-1 is found in endosomes in endothelial cells, the role of endosomal ECE-1 is unclear. ECE-1 degrades the pro-inflammatory neuropeptide substance P (SP) in endosomes to promote recycling and re-sensitization of its neurokinin 1 (NK(1)) receptor. We investigated whether ECE-1 regulates NK(1) receptor re-sensitization and the pro-inflammatory effects of SP in the endothelium.
- Publication
British journal of pharmacology, 2009, Vol 156, Issue 5, p730
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/j.1476-5381.2008.00039.x