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- Title
Calorie restriction alters mitochondrial protein acetylation.
- Authors
Schwer, Bjoern; Eckersdorff, Mark; Li, Yu; Silva, Jeffrey C; Fermin, Damian; Kurtev, Martin V; Giallourakis, Cosmas; Comb, Michael J; Alt, Frederick W; Lombard, David B
- Abstract
Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acetylation during CR. Mitochondrial acetylation changes may play an important role in the pro-longevity CR response.
- Publication
Aging cell, 2009, Vol 8, Issue 5, p604
- ISSN
1474-9726
- Publication type
Journal Article
- DOI
10.1111/j.1474-9726.2009.00503.x