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- Title
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.
- Authors
Jiménez-Hidalgo, María; Santos-Ocaña, Carlos; Padilla, Sergio; Villalba, José M; López-Lluch, Guillermo; Martín-Montalvo, Alejandro; Minor, Robin K; Sinclair, David A; de Cabo, Rafael; Navas, Plácido
- Abstract
The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals.
- Publication
Aging cell, 2009, Vol 8, Issue 2, p140
- ISSN
1474-9726
- Publication type
Journal Article
- DOI
10.1111/j.1474-9726.2009.00461.x