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- Title
The relationship between cigarette smoking, endothelial function and intrauterine growth restriction in human pregnancy.
- Authors
Quinton, A E; Cook, C-M; Peek, M J
- Abstract
This study examined the relationship of cigarette smoking and endothelial function in pregnant women by comparing smokers with nonsmokers. Endothelial function was assessed at 28-32 weeks of gestation by flow-mediated dilatation (FMD) using ultrasound of the brachial artery. The initial FMD was significantly different between the smoking group (n = 21) at 4.0 +/- 2.3, indicating endothelial dysfunction, and the nonsmoking group (n = 20) at 9.7 +/- 4.0 (P < 0.001). After smoking, this difference in the groups persisted. Babies who were growth restricted (<10th percentile) had mothers with a significantly lower FMD, that is endothelial dysfunction. This work demonstrates persistent endothelial dysfunction in smoking pregnant women.
- Publication
BJOG : an international journal of obstetrics and gynaecology, 2008, Vol 115, Issue 6, p780
- ISSN
1471-0528
- Publication type
Journal Article
- DOI
10.1111/j.1471-0528.2008.01691.x