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- Title
Superior temporal gyrus spectral abnormalities in schizophrenia.
- Authors
Edgar, J Christopher; Hanlon, Faith M; Huang, Ming-Xiong; Weisend, Michael P; Thoma, Robert J; Carpenter, Bruce; Hoechstetter, Karsten; Cañive, José M; Miller, Gregory A
- Abstract
Considerable evidence indicates early auditory stimulus processing abnormalities in schizophrenia, but the mechanisms are unclear. The present study examined oscillatory phenomena during a paired-click paradigm in the superior temporal gyrus (STG) as a possible core problem. The primary question addressed is whether first click and/or second click group differences in the time-domain evoked response in patients with schizophrenia are due to (1) group differences in the magnitude of poststimulus oscillatory activity, (2) group differences in poststimulus phase-locking, and/or (3) group differences in the magnitude of ongoing background oscillatory activity. Dense-array magnetoencephalography from 45 controls and 45 patients with schizophrenia produced left- and right-hemisphere STG 50- and 100-ms time-frequency evoked, phase-locking, and total power measures. Whereas first click 100-ms evoked theta and alpha abnormalities were observed bilaterally, evoked low beta-band differences were specific to the left hemisphere. Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure.
- Publication
Psychophysiology, 2008, Vol 45, Issue 5, p812
- ISSN
0048-5772
- Publication type
Journal Article
- DOI
10.1111/j.1469-8986.2008.00682.x