We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies.
- Authors
Johnson, Alexandra M; Dale, Russell C; Wienholt, Louise; Hadjivassiliou, Marios; Aeschlimann, Daniel; Lawson, John A
- Abstract
A 4-year-old boy presented with occipital seizures but normal initial neuroimaging and proved refractory to antiepileptic medications. On repeat neuroimaging after 1 year, he had developed bi-occipital calcification and was then found to have positive coeliac serology. He was diagnosed with coeliac disease, epilepsy, and cerebral calcifications (CEC) and became seizure free after starting the gluten-free diet. Positive antibody binding to neurons and glia was demonstrated on indirect immunofluorescence. High levels of immunoglobulin-A directed against transglutaminase isoenzyme 6 (TG6) were found in the patient's serum. The positive response to the diet, TG6 antibodies, and neuronal antibody binding suggest that CEC might be autoimmune in nature, as in other extra-intestinal manifestations of gluten-related diseases, such as gluten ataxia.
- Publication
Developmental medicine and child neurology, 2013, Vol 55, Issue 1, p90
- ISSN
1469-8749
- Publication type
Journal Article
- DOI
10.1111/j.1469-8749.2012.04369.x