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- Title
Association of enteroaggregative Escherichia coli with irritable bowel syndrome.
- Authors
Sobieszczańska, B M; Osek, J; Waśko-Czopnik, D; Dworniczek, E; Jermakow, K
- Abstract
Increased numbers of faecal Enterobacteriaceae are observed among patients with irritable bowel syndrome. Escherichia coli strains are present in the lower intestine of humans, and may include several potentially pathogenic adhesive pathotypes. The aim of this study was to determine whether there were differences between the adhesive pathotypes of E. coli strains recovered from stool specimens of patients with irritable bowel syndrome and those recovered from healthy controls. The ability of E. coli isolates to adhere to cultured epithelial cells was assessed in an in-vitro adherence assay with HEp-2 cells. Enteroaggregative E. coli (EAEC) strains were isolated significantly more frequently (p <0.00001) from patients with irritable bowel syndrome (81.8%) than from healthy controls (32.3%). However, despite this association, the precise role of the EAEC pathotype in irritable bowel syndrome remains to be determined.
- Publication
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2007, Vol 13, Issue 4, p404
- ISSN
1198-743X
- Publication type
Journal Article
- DOI
10.1111/j.1469-0691.2006.01669.x