We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.
- Authors
Popat, R A; Van Den Eeden, S K; Tanner, C M; Kamel, F; Umbach, D M; Marder, K; Mayeux, R; Ritz, B; Ross, G W; Petrovitch, H; Topol, B; McGuire, V; Costello, S; Manthripragada, A D; Southwick, A; Myers, R M; Nelson, L M
- Abstract
In 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine animal models of Parkinson's disease (PD), caffeine protects neurons by blocking the adenosine receptor A2A (ADORA2A). Caffeine is primarily metabolized by cytochrome P450 1A2 (CYP1A2). Our objective was to examine whether ADORA2A and CYP1A2 polymorphisms are associated with PD risk or modify the caffeine-PD association.
- Publication
European journal of neurology, 2011, Vol 18, Issue 5, p756
- ISSN
1468-1331
- Publication type
Journal Article
- DOI
10.1111/j.1468-1331.2011.03353.x