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- Title
Lopinavir protein binding in HIV-1-infected pregnant women.
- Authors
Aweeka, F T; Stek, A; Best, B M; Hu, C; Holland, D; Hermes, A; Burchett, S K; Read, J; Mirochnick, M; Capparelli, E V; International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1026s Protocol Team
- Abstract
Pregnancy may alter protein binding (PB) of highly bound protease inhibitors due to changes in plasma concentrations of albumin and alpha-1 acid glycoprotein (AAG). Small changes in PB can greatly impact the fraction of drug unbound (FU) exerting pharmacological effect. We report lopinavir (LPV) PB during third trimester (antepartum, AP) compared to > or =1.7 weeks postpartum (PP) to determine if FU changes compensate for reduced total concentrations reported previously.
- Publication
HIV medicine, 2010, Vol 11, Issue 4, p232
- ISSN
1468-1293
- Publication type
Journal Article
- DOI
10.1111/j.1468-1293.2009.00767.x