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- Title
A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection.
- Authors
Youle, M; Osio, M; ALCAR Study Group
- Abstract
Nucleoside reverse transcriptase inhibitors (NRTIs) disrupt neuronal mitochondrial DNA synthesis, resulting in antiretroviral toxic neuropathy (ATN). Acetyl-L-carnitine (ALCAR) enhances neurotrophic support of sensory neurones, potentially providing symptom relief and nerve regeneration.
- Publication
HIV medicine, 2007, Vol 8, Issue 4, p241
- ISSN
1464-2662
- Publication type
Journal Article
- DOI
10.1111/j.1468-1293.2007.00467.x