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Title
Limitation of exercise capacity in nucleoside-treated HIV-infected patients with hyperlactataemia.
Authors
Duong, M; Dumas, J P; Buisson, M; Martha, B; Piroth, L; Grappin, M; Waldner, A; Chavanet, P; Portier, H
Abstract
Inhibition of DNA polymerase gamma by nucleoside reverse transcriptase inhibitors (NRTIs) can cause mitochondrial dysfunction and cellular toxicity. Hyperlactataemia, which is a consequence of a shift in the metabolism of pyruvate, is an indicator of nucleoside-related mitochondrial toxicity.