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Title
What ever happened to N-of-1 trials? Insiders' perspectives and a look to the future.
Authors
Kravitz, Richard L; Duan, Naihua; Niedzinski, Edmund J; Hay, M Cameron; Subramanian, Saskia K; Weisner, Thomas S
Abstract
When feasible, randomized, blinded single-patient (n-of-1) trials are uniquely capable of establishing the best treatment in an individual patient. Despite early enthusiasm, by the turn of the twenty-first century, few academic centers were conducting n-of-1 trials on a regular basis.
Publication
The Milbank quarterly, 2008, Vol 86, Issue 4, p533