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- Title
Immunomodulation confers herbicide resistance in plants.
- Authors
Almquist, Kurt C; Niu, Yongqing; McLean, Michael D; Mena, Frank L; Yau, Kerrm Y F; Brown, Kirk; Brandle, Jim E; Hall, J Christopher
- Abstract
In order to create a novel mechanism for herbicide resistance in plants, we expressed a single-chain antibody fragment (scFv) in tobacco with specific affinity to the auxinic herbicide picloram. Transgenic tobacco plants and seedlings expressing this scFv against picloram were protected from its effect in a dose-dependent manner. This is the first successful use of an antibody to confer in vivo resistance to a low molecular weight xenobiotic (i.e. < 1000 Da). Our results suggest the possibility for a generic antibody-based approach to create crops resistant to low molecular weight xenobiotics for subsequent use in the bioremediation of contaminated soils, crop protection and as novel selectable markers.
- Publication
Plant biotechnology journal, 2004, Vol 2, Issue 3, p189
- ISSN
1467-7652
- Publication type
Journal Article
- DOI
10.1111/j.1467-7652.2004.00060.x