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- Title
Protective effects of taurine on human hair follicle grown in vitro.
- Authors
Collin, C; Gautier, B; Gaillard, O; Hallegot, P; Chabane, S; Bastien, P; Peyron, M; Bouleau, M; Thibaut, S; Pruche, F; Duranton, A; Bernard, B A
- Abstract
Taurine is a naturally occurring beta-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological functions, including immunomodulatory and antifibrotic. Taking advantage of the ability of human hair follicle grown in vitro to recapitulate most of the characteristic features of normal hair follicle in vivo, we studied (i) taurine uptake by isolated human hair follicles; (ii) its effects on hair growth and survival rate; and (iii) its protective potential against transforming growth factor (TGF)-beta1, an inhibitor of in vitro hair growth and a master switch of fibrotic program. We showed that taurine was taken up by the connective tissue sheath, proximal outer root sheath and hair bulb, promoted hair survival in vitro and prevented TGF-beta1-induced deleterious effects on hair follicle.
- Publication
International journal of cosmetic science, 2006, Vol 28, Issue 4, p289
- ISSN
1468-2494
- Publication type
Journal Article
- DOI
10.1111/j.1467-2494.2006.00334.x