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- Title
HbA<sub>1c</sub> in adults without known diabetes from southern Europe. Impact of the new diagnostic criteria in clinical practice.
- Authors
Bernal-Lopez, M. R.; Santamaría-Fernandez, S.; Lopez-Carmona, D.; Tinahones, F. J.; Mancera-Romero, J.; Peña-Jimenez, D.; Jansen-Chaparro, S.; Baca-Osorio, A. J.; Cuesta-Muñoz, A. L.; Serrano-Rios, M.; Gomez-Huelgas, R.
- Abstract
Diabet. Med. 28, 1319-1322 (2011) Abstract Aims To analyse the differences in the prevalence of diabetes and dysglycaemia using fasting plasma glucose and HbA1c criteria. Methods Analytical cross-sectional study undertaken in a random sample of 2144 individuals (age 18-80 years) without known diabetes from the primary care setting in Malaga (Spain). Dysglycaemia was defined as fasting plasma glucose 5.6-6.9 mmol/l or HbA1c 39-46 mmol/mol (5.7-6.4%) and diabetes as fasting plasma glucose ≥ 7.0 mmol/l or HbA1c≥ 48 mmol/mol (≥ 6.5%). Results The proportion of subjects who were normoglycaemic was significantly higher using fasting plasma glucose than HbA1c (83.5 vs. 65%) ( P < 0.0001). Compared with fasting plasma glucose, HbA1c detects more cases of dysglycaemia (32 vs. 14.8%) ( P < 0.0001) and diabetes (3 vs. 1.7%) ( P < 0.0001). Conclusions In our environment, using HbA1c for the diagnosis of pre-diabetes and diabetes could increase the target population for preventive and therapeutic measures. Further cost-effectiveness studies are needed before the widespread diagnostic use of HbA1c can be recommended.
- Publication
Diabetic Medicine, 2011, Vol 28, Issue 11, p1319
- ISSN
0742-3071
- Publication type
Academic Journal
- DOI
10.1111/j.1464-5491.2011.03317.x