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- Title
Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin have no independent prognostic relevance for cancer-specific survival in surgically treated squamous cell carcinoma of the penis.
- Authors
May, Matthias; Burger, Maximilian; Otto, Wolfgang; Hakenberg, Oliver W; Wieland, Wolf F; May, Dieter; Hofstädter, Ferdinand; Götz, Stefanie; Niessl, Nina; Fritsche, Hans-Martin; Birnkammer, Kristina; Gilfrich, Christian; Peter, Julia; Jain, Anjun; Koch, Stefan; Lebentrau, Steffen; Riedmiller, Hubertus; Rössler, Wolfgang; Denzinger, Stefan; Brookman-May, Sabine; Gunia, Sven
- Abstract
What's known on the subject? and what does the study add?: Only little and partly contradictory data are currently published about the prognostic role of immunohistochemically detectable proliferation-associated biomarkers in surgically treated squamous cell carcinoma of the penis (SCCP), and no data are available at present about their usefulness for refining the delineation between different Broders' grading categories (e.g. still G2 or just G3 SCCP?). Moreover, the accuracy of various conventional histopathological parameters for predicting cancer-specific survival (CSS) in surgically treated SCCP has not been systematically evaluated yet. Based on the so far largest study cohort encompassing 158 consecutive patients with surgically treated PSCCs characterised by means of a central histopathological review, our data add the following to the currently available literature: (i) Ki-67, mini-chromosome maintenance 2 protein (MCM2), and geminin indicate a more aggressive behaviour in SCPP but do not represent independent prognostic parameters in the multivariable analysis in terms of CSS, (ii) these three biomarkers are not helpful for refining the delineation between different Broders' grading categories at the immunohistochemical level, and (iii) the conventional histopathological parameters staging, grading, nodal involvement, and lymphovascular invasion are independent prognostic parameters that together achieve a predictive accuracy of 82% for CSS.
- Publication
BJU international, 2013, Vol 112, Issue 4, pE383
- ISSN
1464-410X
- Publication type
Journal Article
- DOI
10.1111/j.1464-410X.2012.11735.x