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- Title
Use of low free to total PSA ratio in prostate cancer screening: detection rates, clinical and pathological findings in Brazilian men with serum PSA levels <4.0 ng/mL.
- Authors
Faria, Eliney Ferreira; Carvalhal, Gustavo F; dos Reis, Rodolfo Borges; Tobias-Machado, Marcos; Vieira, Renê A C; Reis, Leonardo O; Nogueira, Lucas; Machado, Roberto Dias; Freitas, Celso H, Jr; Magnabosco, Wesley J; Mauad, Edmundo C; Carvalho, André Lopes
- Abstract
What's known on the subject? and What does the study add? In spite of its low specificity, PSA is the most widely used screening test for prostate cancer (PCa), and is considered the main cause of the stage migration recently observed. The ratio of free to total PSA (%fPSA) has been shown to increase PSA accuracy in cancer detection; however, few screening studies have systematically evaluated its role in cancer detection rates in men with PSA levels <4.0 ng/mL and normal DRE. The present study supports a possible role of %fPSA as an adjunct to screening in men with total PSA 2.5-4.0 ng/mL and normal DRE, with a marked increase in cancer detection rates in a large Brazilian PCa screening study. We believe that %fPSA maybe a useful refinement to biopsy indications in men with low PSA levels.
- Publication
BJU international, 2012, Vol 110, Issue 11 Pt B, pE653
- ISSN
1464-410X
- Publication type
Journal Article
- DOI
10.1111/j.1464-410X.2012.11398.x