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- Title
Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.
- Authors
McKinnon, E; Morahan, G; Nolan, D; James, I; Diabetes Genetics Consortium
- Abstract
The Major Histocompatibility Complex (MHC) is a highly polymorphic region on chromosome 6 encompassing the human leucocyte antigen (HLA)-DQ/DR loci most predictive of susceptibility to type 1 diabetes (T1D). To assess the contribution of other MHC genes, in this exploratory analysis of Type 1 Diabetes Genetics Consortium (T1DGC) family data we characterize association between susceptibility and MHC single nucleotide polymorphism (SNP) genotype, with an emphasis on effects of genetic variation additional to carriage of predisposing or protective MHC haplotypes.
- Publication
Diabetes, obesity & metabolism, 2009, Vol 11 Suppl 1, p92
- ISSN
1463-1326
- Publication type
Journal Article
- DOI
10.1111/j.1463-1326.2008.01009.x