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- Title
Biomarkers of body iron stores and risk of developing type 2 diabetes.
- Authors
Rajpathak, S N; Wylie-Rosett, J; Gunter, M J; Negassa, A; Kabat, G C; Rohan, T E; Crandall, J; Diabetes Prevention Program (DPP) Research Group
- Abstract
Iron may contribute to the pathogenesis of type 2 diabetes mellitus (DM) by inducing oxidative stress and interfering with insulin secretion. Elevated ferritin levels are associated with increased DM risk among healthy individuals. However, it is yet unknown if ferritin predicts DM incidence among high-risk individuals with impaired glucose tolerance (IGT). Furthermore, the association between soluble transferrin receptors (sTfR), a novel marker of iron status, and DM risk has not yet been prospectively investigated in these individuals. We conducted this study to evaluate the association between baseline levels of ferritin and sTfR and the risk of developing DM among overweight and obese individuals at high risk of DM.
- Publication
Diabetes, obesity & metabolism, 2009, Vol 11, Issue 5, p472
- ISSN
1463-1326
- Publication type
Journal Article
- DOI
10.1111/j.1463-1326.2008.00985.x