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- Title
The risk of dysplasia and cancer in the ileal pouch mucosa after restorative proctocolectomy for ulcerative proctocolitis is low: a long-term term follow-up study.
- Authors
Börjesson, L; Willén, R; Haboubi, N; Duff, S E; Hultén, L
- Abstract
Some of the rare complications reported in patients with an ileopouch anal anastomosis (IPAA) after coloectomy for chronic ulcerative colitis are dysplasia and carcinoma. The supposed pathway is for the ileal pouch mucosa to go through adaptational changes then is to progress through the phases of chronic pouchitis, dysplasia and subsequently to adenocarcinoma. In many of these studies however, the dysplasia-cancer sequence is inconclusive since the carcinoma might have developed from the ileal mucosa itself or from residual viable rectal mucosa left behind. The purpose of this study was therefore to study the long-term ileal mucosal adaptation patterns and the incidence and grading of dysplasia in the ileal pouch mucosa in patients previously operated on for ulcerative proctocolitis.
- Publication
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2004, Vol 6, Issue 6, p494
- ISSN
1462-8910
- Publication type
Journal Article
- DOI
10.1111/j.1463-1318.2004.00716.x