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- Title
Subversion of innate immune responses by bacterial hindrance of NF-κB pathway.
- Authors
Le Negrate, Gaëlle
- Abstract
Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.
- Publication
Cellular microbiology, 2012, Vol 14, Issue 2, p155
- ISSN
1462-5822
- Publication type
Journal Article
- DOI
10.1111/j.1462-5822.2011.01719.x