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- Title
Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.
- Authors
Johnson, Trevor N; Rostami-Hodjegan, Amin
- Abstract
(i) To describe an example of the development work required for building a 'pediatric physiologically based pharmacokinetic' (P-PBPK) model (Simcyp Pediatric ADME Simulator), (ii) to replicate pediatric clinical studies and undertake theoretical studies to show the potential applications of mechanistic PBPK in pediatric drug clinical investigation and practice, with emphasis on pediatric anesthesia.
- Publication
Paediatric anaesthesia, 2011, Vol 21, Issue 3, p291
- ISSN
1460-9592
- Publication type
Journal Article
- DOI
10.1111/j.1460-9592.2010.03323.x