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Title
A randomized, controlled trial of aprotinin in neonates undergoing open-heart surgery.
Authors
Williams, Glyn D; Ramamoorthy, Chandra; Pentcheva, Krassimira; Boltz, M Gail; Kamra, Komal; Reddy, V Mohan
Abstract
Neonates undergoing open-heart surgery are especially at risk for massive bleeding and pronounced inflammation. The efficacy of aprotinin, a serine protease inhibitor, at ameliorating these adverse effects of cardiopulmonary bypass has not been clearly demonstrated in neonates.