We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neurogranin phosphorylation fine-tunes long-term potentiation.
- Authors
Zhong, Ling; Kaleka, Kanwardeep S; Gerges, Nashaat Z
- Abstract
Learning-related potentiation of synaptic strength at Cornu ammonis subfield 1 (CA1) hippocampal excitatory synapses is dependent on neuronal activity and the activation of glutamate receptors. However, molecular mechanisms that regulate and fine-tune the expression of long-term potentiation (LTP) are not well understood. Recently it has been indicated that neurogranin (Ng), a neuron-specific, postsynaptic protein that is phosphorylated by protein kinase C, potentiates synaptic transmission in an LTP-like manner. Here, we report that a Ng mutant that is unable to be phosphorylated cannot potentiate synaptic transmission in rat CA1 hippocampal neurons and results in a submaximal expression of LTP. Our results provide the first evidence that the phosphorylation of Ng can regulate LTP expression.
- Publication
The European journal of neuroscience, 2011, Vol 33, Issue 2, p244
- ISSN
1460-9568
- Publication type
Journal Article
- DOI
10.1111/j.1460-9568.2010.07506.x