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- Title
Angiotensin II receptor antagonist reduces subsequent uterine arterial dysfunction in pregnant offspring of protein-restricted rat dams.
- Authors
Saito, Tomomi; Musha, Yuka; Miyakawa, Miho; Itoh, Shigeru; Ohtsuji, Mareki; Hanson, Mark A; Takeda, Satoru
- Abstract
A low-protein diet (LPD) during pregnancy induces vascular dysfunction and hypertension in the offspring, prevented by administration of an angiotensin II type 1 (AT(1)) receptor antagonist in early life to the offspring. Whether such protection extends to subsequent pregnancy is unknown; we therefore hypothesized that administration of a specific AT(1) receptor antagonist (losartan) in early life to offspring of LPD dams would improve vascular dysfunction in their uterine arteries when they, in turn, were pregnant.
- Publication
The journal of obstetrics and gynaecology research, 2012, Vol 38, Issue 3, p483
- ISSN
1447-0756
- Publication type
Journal Article
- DOI
10.1111/j.1447-0756.2011.01737.x