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- Title
Low expression of XIAP-associated factor 1 in human colorectal cancers.
- Authors
Ma, Tian Le; Ni, Pei Hua; Zhong, Jie; Tan, Ji Hong; Qiao, Min Min; Jiang, Shi Hu
- Abstract
Eight cellular homologs of the inhibitors-of-apoptosis proteins (IAP) have been identified in humans and of them, the X-linked IAP (XIAP) is the most potent. XIAP-associated factor 1 (XAF1) is a newly discovered XIAP-binding protein that negatively regulates the caspase-inhibiting activity of XIAP. It is either not expressed or present at extremely low levels in many cancer cell lines. The aims of the present study were: (i) to investigate the expression of XAF1 in human colorectal cancers (CRC) both in vitro and in vivo, and (ii) to evaluate the possibility of XAF1 as a new tumor marker.
- Publication
Chinese journal of digestive diseases, 2005, Vol 6, Issue 1, p10
- ISSN
1443-9611
- Publication type
Journal Article
- DOI
10.1111/j.1443-9573.2005.00180.x