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- Title
Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway.
- Authors
Showalter, Shayna L; Wang, Ziqiu; Costantino, Christina L; Witkiewicz, Agnieszka K; Yeo, Charles J; Brody, Jonathan R; Carr, Brian I
- Abstract
Available medical therapies against pancreatic cancer are largely ineffective and have many side-effects. Physiologically, vitamins K1 and K2 (VK) act as co-factors for gamma-carboxylation of prothrombin and other coagulation factors. In previous studies, VK analogs have been found to have potent negative effects on the survival of various cancer cells. We hypothesized that the well-tolerated and naturally occurring VK1 and VK2 may be used to inhibit pancreatic cancer cell survival.
- Publication
Journal of gastroenterology and hepatology, 2010, Vol 25, Issue 4, p738
- ISSN
1440-1746
- Publication type
Journal Article
- DOI
10.1111/j.1440-1746.2009.06085.x