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- Title
Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice.
- Authors
Larter, Claire Z; Yeh, Matthew M; Van Rooyen, Derrick M; Teoh, Narci C; Brooling, John; Hou, Jing Yun; Williams, Jacqueline; Clyne, Matthew; Nolan, Christopher J; Farrell, Geoffrey C
- Abstract
We previously reported that steatohepatitis develops in obese, hypercholesterolemic, diabetic foz/foz mice fed a high-fat (HF) diet for 12 months. We now report earlier onset of steatohepatitis in relation to metabolic abnormalities, and clarify the roles of dietary fat and bodily lipid partitioning on steatosis severity, liver injury and inflammatory recruitment in this novel non-alcoholic steatohepatitis (NASH) model.
- Publication
Journal of gastroenterology and hepatology, 2009, Vol 24, Issue 10, p1658
- ISSN
1440-1746
- Publication type
Journal Article
- DOI
10.1111/j.1440-1746.2009.05996.x