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- Title
Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer.
- Authors
Srivastava, Anvesha; Pandey, Sachchida Nand; Dixit, Manjusha; Choudhuri, Gourdas; Mittal, Balraj
- Abstract
Gallbladder carcinoma (GBC) usually arises in the background of gallstone disease which may be causatively related to decreased gallbladder contractility. Cholecystokinin receptor A (CCK-AR) mediates signals resulting in gallbladder contraction. Deteriorating gallbladder contraction promotes gallstone formation. A common genetic polymorphism of CCK-AR may be causatively associated with the risk of gallstone and GBC. This study aimed to understand the association of CCK-AR Pst I polymorphism in gallstone disease with gallbladder cancer.
- Publication
Journal of gastroenterology and hepatology, 2008, Vol 23, Issue 6, p970
- ISSN
1440-1746
- Publication type
Journal Article
- DOI
10.1111/j.1440-1746.2007.05170.x