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- Title
Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis.
- Authors
Izzo, Francesco; Montella, Maurizio; Orlando, Antonio Pio; Nasti, Guglielmo; Beneduce, Gerardo; Castello, Giuseppe; Cremona, Francesco; Ensor, C Mark; Holtzberg, Frederick W; Bomalaski, John S; Clark, Mike A; Curley, Steven A; Orlando, Raffaele; Scordino, Fabrizio; Korba, Brent E
- Abstract
The arginine-degrading enzyme, arginine deiminase conjugated to polyethylene glycol (ADI-SS PEG 20,000 mw), reduces extracellular arginine, has minimal toxicity, decreases tumor burden and improves liver function in patients with chronic hepatitis C virus infection (HCV) and inoperable hepatocellular carcinoma (HCC). Reduced extracellular arginine inhibits viral replication through unknown mechanisms. It is hypothesized that ADI-SS PEG 20,000 mw reduces HCV viral titers through nitric oxide (NO)-dependent effects.
- Publication
Journal of gastroenterology and hepatology, 2007, Vol 22, Issue 1, p86
- ISSN
0815-9319
- Publication type
Journal Article
- DOI
10.1111/j.1440-1746.2006.04463.x