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- Title
Characterization of CD8<sup>+</sup> T-cell responses in HIV-1-exposed seronegative commercial sex workers from Nairobi, Kenya.
- Authors
Alimonti, Judie B.; Kimani, Joshua; Matu, Lucy; Wachihi, Charles; Kaul, Rupert; Plummrt, Francis A.; Fowke, Krith R.
- Abstract
CD8+ T-lymphocyte responses are crucial to the control of HIV-1; therefore, studying the CD8+ immune response in a naturally resistant population could provide valuable insights into an effective anti-HIV response in healthy uninfected individuals. Approximately 5–10% of the women in the Pumwani Commercial Sex Worker cohort in Nairobi, Kenya, have been highly exposed to HIV-1 yet remain HIV-IgG-seronegative and HIV-PCR negative (HIVES). As IFN-γ production correlates to cytotoxic function, the CD8+ T-lymphocyte IFN-γ response to HIV p24 peptides was compared in HIVES and HIV-infected (HIV+) individuals. Almost 40% of the HIVES had a CD8+ IFN-γ+ response that was five times lower in magnitude than that of the HIV+ group. The breadth of the response in HIVES was very narrow and focused primarily on one peptide that is similar to the protective KK10 peptide. In the HIV+ group, low peripheral CD4+ counts negatively influenced the number of CD8+ cells producing IFN-γ, which may undermine the ability to control HIV. Overall, many of the HIVES women possess a HIV-1 p24-specific CD8+ IFN-γ response, providing evidence to the specificity needed for an effective HIV vaccine.
- Publication
Immunology & Cell Biology, 2006, Vol 84, Issue 5, p482
- ISSN
0818-9641
- Publication type
Academic Journal
- DOI
10.1111/j.1440-1711.2006.01455.x