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- Title
Renal inflammation, autoimmunity and salt-sensitive hypertension.
- Authors
Rodríguez-Iturbe, Bernardo; Franco, Martha; Tapia, Edilia; Quiroz, Yasmir; Johnson, Richard J
- Abstract
1. The present article reviews the role of immune-competent cells infiltrating the kidney and their association with oxidative stress and renal angiotensin activity in the development of salt-sensitive hypertension. 2. We discuss changes in the pressure-natriuresis relationship resulting from renal inflammation and its improvement resulting from immunosuppressive treatment. 3. The potential role of T-cell-driven reactivity in sustaining the renal inflammation is examined in the light of accumulating evidence of autoimmune mechanisms in experimental and clinical hypertension.
- Publication
Clinical and experimental pharmacology & physiology, 2012, Vol 39, Issue 1, p96
- ISSN
1440-1681
- Publication type
Journal Article
- DOI
10.1111/j.1440-1681.2011.05482.x