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- Title
Primary cutaneous diffuse leiomyosarcoma with desmoplasia.
- Authors
Choy, Carolyn; Cooper, Alan; Kossard, Steven
- Abstract
A 65-year-old man presented with an indurated plaque over his left cheek and left neck. An initial punch biopsy of skin showing increased smooth muscle bundles was consistent with a diagnosis of smooth muscle hamartoma. A second incisional skin biopsy revealed a well-differentiated smooth muscle proliferation invading into the dermis and subcutaneous fat in a diffusely infiltrative pattern and with a desmoplastic component, suggesting a diagnosis of desmoplastic leiomyosarcoma. Resection of the tumour confirmed the presence of a cytologically low grade leiomyosarcoma with an insidious infiltrative growth pattern. This rare pattern of diffuse leiomyosarcoma is important to recognize as the histological features are subtle and may potentially constitute a pitfall in histological diagnosis in a small biopsy specimen. In addition, our case illustrates overlapping morphology between diffuse and desmoplastic types of leiomyosarcoma.
- Publication
The Australasian journal of dermatology, 2006, Vol 47, Issue 4, p291
- ISSN
0004-8380
- Publication type
Journal Article
- DOI
10.1111/j.1440-0960.2006.00298.x