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- Title
A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum.
- Authors
Torres, Avital; Hochberg, Malka; Pergament, Inna; Smoum, Reem; Niddam, Valerie; Dembitsky, Valery M; Temina, Marina; Dor, Inka; Lev, Ovadia; Srebnik, Morris; Enk, Claes D
- Abstract
A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.
- Publication
European journal of biochemistry, 2004, Vol 271, Issue 4, p780
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.2004.03981.x