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- Title
The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes.
- Authors
Hegg, E L; Que, L, Jr
- Abstract
A 2-His-1-carboxylate facial triad is a common feature of the active sites in a number of mononuclear non-heme iron(II) enzymes. This structural motif was established crystallographically for five different classes of enzymes and inferred from sequence similarity for two other classes. The 2-His-1-carboxylate facial triad anchors the iron in the active site and at the same time maintains three additional cis-oriented sites. These sites can be used to bind other endogenous ligands or exogenous ligands such as substrate and/or O2, giving the metal center great flexibility to use different mechanistic strategies to perform a variety of chemical transformations.
- Publication
European journal of biochemistry, 1997, Vol 250, Issue 3, p625
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.1997.t01-1-00625.x