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- Title
The active species of 'CO2' utilized by formylmethanofuran dehydrogenase from methanogenic Archaea.
- Authors
Vorholt, J A; Thauer, R K
- Abstract
Formylmethanofuran dehydrogenase from methanogenic Archaea catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran, which is an intermediate in methanogenesis from CO2, a biological process yielding approximately 0.3 billion tons of CH4 per year. With the enzyme from Methanosarcina barkeri, it is shown that CO2 rather than HCO3- is the active species of 'CO2' utilized by the dehydrogenase. Evidence is also presented that the enzyme catalyzes a methanofuran-dependent exchange between CO2 and the formyl group of formylmethanofuran. The results are consistent with N-carboxymethanofuran being an intermediate in CO2 reduction to formylmethanofuran.
- Publication
European journal of biochemistry, 1997, Vol 248, Issue 3, p919
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.1997.00919.x