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- Title
Strategies of antioxidant defense.
- Authors
Sies, H
- Abstract
Cellular protection against the deleterious effects of reactive oxidants generated in aerobic metabolism, called oxidative stress, is organized at multiple levels. Defense strategies include three levels of protection; prevention, interception, and repair. Regulation of the antioxidant capacity includes the maintenance of adequate levels of antioxidant and the localization of antioxidant compounds and enzymes. Short-term and long-term adaptation and cell specialisation in these functions are new areas of interest. Control over the activity of prooxidant enzymes, such as NADPH oxidase and NO synthases, is crucial. Synthetic antioxidants mimic biological strategies.
- Publication
European journal of biochemistry, 1993, Vol 215, Issue 2, p213
- ISSN
0014-2956
- Publication type
Journal Article
- DOI
10.1111/j.1432-1033.1993.tb18025.x